Recent COVID-19 outbreaks has forced the Economic Development Australia (EDA)'s flagship annual conference, NEDC20 online.
Originally scheduled to be held at the William Inglis Hotel, the event will remain on November 18 to 20 but shift to a digital platform.
Liverpool Mayor Wendy Waller said moving online provided new opportunities.
"While we are disappointed not to welcome delegates to Liverpool in person as this year's host city, we look forward to bringing delegates a taste of our vibrant and culturally diverse city through innovative means," Mayor Waller said.
"In line with the conference theme, Breaking New Ground - Building a Resilient Future, NEDC20 organisers have thought creatively about how we can deliver a quality program with global relevance.
"By focussing on a digital-only event, we can open the conference up to a broader audience and allow people to participate from the safety and comfort of their home or office."
EDA CEO Jacqueline Brinkman said some of the confirmed speakers include Resilience NSW Commissioner Shane Fitzsimmons, Invest Puerto Rico CEO Rod Miller and ARUP's Australasia Cities Leader Dr Tim Williams.
"In a year without much certainty, what we do know is that NEDC20 will be the one economic development event not to be missed," Ms Brinkman said
"Through interactive live presentations and discussions, global economic development leaders working in industries as diverse as tourism and tertiary education will deliver insights and best practice ideas for leading recovery, building resilience, and transforming local economies in response to the COVID-19 pandemic.
"NEDC20 also provides a unique opportunity to promote your business to economic development leaders from Australia and beyond through sponsorship, raising your company profile and helping to develop or strengthen strategic partnerships."