INGHAMS Enterprises is the latest local business to feel the pinch, announcing 363 job cuts.
After more than 50 years in the local area, Inghams will move their processing operations from their Hoxton Park site to South Australia.
Around 335 workers from the processing plant will be affected, along with 28 workers from the Casula Hatchery.
The hatchery will close on February 22, and the processing plant will close on May 3.
Inghams general manager, Peter Van Vliet, said ongoing feasibility reviews into the constraints on existing facilities, local production volumes and efficiencies resulted in the difficult decision.
"Our most recent review has identified that production volumes at Hoxton Park can now be redirected and more efficiently produced at larger and more modern processing plants within the business," he said.
"Although the reviews have been widely communicated to employees and union representatives over the last five years, the closure was not an easy decision.
"The Hoxton Park site has served us well and we are very proud of the site's achievements during this time."
Mr Van Vliet said customer and product supply will remain unchanged, and the distribution centres at Lurnea and Hoxton Park, and the weigh label and product development areas will continue to operate as normal.
He said the company was working closely with affected staff, exploring redeployment opportunities at Ingleburn and Cardiff facilities, as well as a number of interstate opportunities in Brisbane and Adelaide.